Using chromosome conformation capture (3 C) assay, we also showed that these three enhancer regions interact with the promoter region of MEIS1. A recent report by Lin et al. indicates the region encompassing E1 and E2 as a super-enhancer in Ewing sarcoma with high H3K27Ac correlating to high MEIS1 expression [13]. The gene discussed is MEIS1; the disease is Ewing sarcoma.