IL1B and obesity due to melanocortin 4 receptor deficiency: In conclusion, based on the significant upregulation of target inflammatory IVDD-associated inflammatory mediators, induced by the combined-hResistin and IL-1β stimulation of hIVD cells, compared to that induced by mono-IL-1β stimulation, the promoting effect of hResistin, which is associated with the development of insulin resistance in obesity, on the progression of inflammatory IVDD via upregulation of inflammatory mediators associated with the activation of IL-1β pro-inflammatory cytokine cascade has been observed (Fig. 7).