IFNG and neoplasm: Polymer nanoparticles diffuse efficiently from injection site and accumulate in LNs.31 In the absence of tumor cells at S.C. injection site, diffusion of nanovaccine would result in diminished antigen stimulation on the recruited T cells, leading to the ablation of myeloid cell/CXCL9-CD8+ T cell/IFNγ loop over time.