CD8A and neoplasm: Consistently, although the proportion of tetramer+CD8+ T cells in the LNs and spleen was higher following S.C. vaccination than I.T. vaccination (figure 3E and online supplemental figures S3D), tetramer+CD8+ T cells were dramatically elevated within tumor tissues (69-fold and 117-fold in I.T. group over the control group after the first and final vaccination, respectively, compared with 5.1-fold and 20-fold in the S.C. group, figure 3F).