PC7A facilitates the cytosolic translocation of DNA, inducing cGAS-dependent STING activation.17 Further study showed that PC7A could also bind to STING directly and form biomolecular condensates to initiate the downstream type I IFN expression.18 This vaccine produced potent tumor growth inhibition in multiple tumor models and showed excellent synergy with checkpoint inhibitors.17 The gene discussed is CGAS; the disease is neoplasm.