SHBG and hyperandrogenism: Hirsutism does not correlate directly with androgen circulating levels.12, 17Therefore, whenever clinical hyperandrogenism is undetected, biochemical hyperandrogenism should be evaluated by high-quality assays, measuring total serum testosterone and SHBG.3, 16Conversely, and since this conventional dosage calibration curve is the same used for the male gender, it is quite inaccurate for females, being unable to detect analytical evidence of hyperandrogenism in less severe forms of hirsutism.