Differences in expression of NKX2.1 and COUP-TFII expressing progenitors recapitulate in vivo development as there is decreased expression of COUP-TFII/NR2F2, but not NKX2. 1, in human fetal DS brain (Olmos-Serrano et al., 2016) (Figure 2E). The gene discussed is NKX2-1; the disease is Dravet syndrome.