Differences in expression of NKX2.1 and COUP-TFII expressing progenitors recapitulate in vivo development as there is decreased expression of COUP-TFII/NR2F2, but not NKX2. 1, in human fetal DS brain (Olmos-Serrano et al., 2016) (Figure 2E). Here, NR2F2 is linked to Dravet syndrome.