AML with TLS-ERG fusion gene is estimated to account for nearly 1% of all AML cases.[17] It has been widely recognized that TLS-ERG fusion protein exerts its oncogenic role during the progression of AML is positively correlated with a poor prognosis and high risk of gene mutations, such as complex chromosome abnormalities and hematological malignancies gene mutations.[16] Unfortunately, no fusion genes, cytogenetic studies, or molecular and genetic mutation analyses were performed when the patients receive the first diagnosis of isolated gastric MC. The gene discussed is ERG; the disease is acute myeloid leukemia.