The TLS-ERG fusion gene was first identified in myxoid liposarcoma in 1993 and was derived from the translocation, t(16; 21) (p11; q22).[13,14] Existing evidence has revealed that the TLS-ERG fusion gene is frequently observed in AML, blast crisis of chronic myelocytic leukemia, and Ewing's sarcoma.[15] A comprehensive review of almost 50 ears of literature showed that less than 100 patients with TLS-ERG fusion gene have been documented.[16] Up to now, there have been no clinical literature published on MS accompanied by TLS-ERG fusion gene. Here, ERG is linked to chronic myelogenous leukemia, BCR-ABL1 positive.