IL18 and pericardial effusion: Pericardial effusion is a rare manifestation of FD.[11] The presence of lysosomal Gb3 and related globotriaosylsphingosine in pericardial fluid from patients with FD and elevated IL-6 and IL-18 levels in pericardial fluid and plasma, are markers of FD-associated cardiomyopathy severity.