Fabry disease (FD) is an X-chromosome-linked inherited disorder of glycosphingolipid metabolism caused by deficient or absent lysosomal alpha galactosidase A activity, which results in progressive build-up of globotriaosylceramide in the cells of various tissues.[1,2] The severity of FD also depends on sex, with males being more severely affected than females. This evidence concerns the gene GLA and Fabry disease.