INS and COVID-19: This signature may be useful for the assessment of prognostic features[15] of COVID-19 and the therapeutic targeting of potential drugs.[7,17] PKR plays a role in the course of COVID-19 infection, including a regulatory role[6,18] in the virus-induced stress response and induces possible insulin resistance,[6] contributing to the progression of pathophysiological processes in COVID-19 patients with co-morbid diabetes.