Possible explanations could be that (1) MALT1 induces immune dysregulation or T‐cell‐mediated autoimmunity via suppressing the differentiation of regulatory T cells into Th1 cells and Th17 cells, thus abnormally unregulated MALT1 could reveal a high risk of AS.10, 19. The gene discussed is MALT1; the disease is Autoimmunity.