When comparing both CRP and PCT levels for all bacterial infections in this study (bacteremia plus leptospirosis plus rickettsiosis) against viral infections, both biomarkers were significantly higher in all bacterial groups than in the dengue group, with a median CRP plasma level of 93 mg/L (IQR 19–166) vs. 5.8 mg/L (2.8–18.1) and PCT of 0.90 ng/mL (IQR 0.23–15) vs. 0.29 ng/mL (IQR 0.15–0.65), respectively (both p < 0.001). This evidence concerns the gene CRP and bacterial infectious disease with sepsis.