A certain amount of inflammatory response is paramount to normal healthy gestation, however, its exaggeration by the imbalance between pro-inflammatory (TNF-α, IL-6, and IL-8) and anti-inflammatory (IL-10, and IL-4) cytokines/chemokines, and the stimulation of different signaling molecules may sequel in many complications, such as preterm labor, IUGR, and spontaneous abortion, which may even increase the risk of morbidity and mortality to both the mother and their offspring [47,48]. This evidence concerns the gene TNF and abortion.