CD4 and amyotrophic lateral sclerosis: The immunoregulatory effects of bee venom may play roles in research aimed at immunomodulation of pathologies such as multiple sclerosis and amyotrophic lateral sclerosis; this effect is attributed to the decrease in microglial activation and infiltration of Th1 lymphocytes (CD4+ and IFN-γ) and Th17 cells (CD4+ and IL-17) and the favorable recruitment of Tregs [40,118,119].