Specifically, the peroxisome proliferator activated receptors (PPARs), the pregnane X receptors (PXR), the constitutive androstane receptor (CAR), the liver X receptor (LXR), the farnesoid X receptor (FXR) and acyl hydrocarbon receptor (AHR) have been shown to participate in non-alcohol fatty liver disease induction [20,21]. The gene discussed is NR1I2; the disease is alcoholic fatty liver disease.