PPIB and carpal tunnel syndrome: Lastly, one study injected BoNT-B in patients with carpal tunnel syndrome [46], dividing 2500 units of RimabotulinumtoxinB into three intramuscular injections (one for each muscle), under EMG guidance to identify opponens digiti minimi and flexor digiti minimi, and anatomically locating palmaris brevis muscle [46].