KIF1A and hereditary spastic paraplegia: One of the KIF1A variants linked to human hereditary spastic paraplegia (SPG30), p.I1026T (Figure 1A), lies in this same uncharacterized, but highly conserved region within the human UNC-104 ortholog, KIF1A (Citterio et al. 2015).Modeling this human variant inC. elegansmay offer insight into how the function of SPG30 motor protein may be altered.