A number of non‐invasive models are available to predict the presence of varices usually incorporating varying cut off levels for platelet count, with additional features including serum albumin and alkaline phosphatase (Newcastle Risk Score),34 the Baveno—V1 criteria for varices screening (based on platelet count and Fibroscan reading),35 whilst in another multivariate analysis a platelet count <140 000 and a Mayo risk score of 4.5 or greater were independent predictors of varices and identified patients who need a screening endoscopy.11 The gene discussed is ALB; the disease is varicose disease.