Quantitative proteomics analysis of NETs in response to PMA and A23187 in neutrophils from rheumatoid arthritis and SLE indicated PMA-induced NETs contained proteins of annexin family, azurocidin, and histone H3, whereas A23187 enriched CAMP/LL37, CRISP3, lipocalin, IL-8, and PADI4 (Chapman et al. 2019). This evidence concerns the gene CRISP3 and rheumatoid arthritis.