ICAM1 and inflammatory response: In particular, comparing the highly unsaturated chemical composition of endothelial LDs formed as a result of inflammation in the present study (evidenced here by ICAM-1 overexpression; Fig. 6) with LDs features linked to apoptosis induced by Fas ligand [10] (featured by unsaturated lipids with an average number of C=C bonds equalled 1.7, or rich in cholesterols with an average number of C=C bonds equalled 0.95) [26], underscored that the high level of endothelial LDs unsaturation could be recognized as a hallmark of vascular inflammation.