For example, retroviral transduction of mouse bone marrow cells to overexpress human JAK3 A572V followed by transplantation into lethally irradiated mice resulted in megakaryocytic hyperplasia and lymphoproliferative disorders [11], including a T-ALL like disease, with ligand-independent proliferation of T cells [17]. The gene discussed is JAK3; the disease is acute lymphoblastic leukemia.