Compared with the HFD group, Nrf2 expression was significantly increased after SIL and LPs intervention (p < 0.01, Figure 7), and the expression levels of HO-1 and NQO1 in the SIL and LP-200 groups significantly increased (p < 0.05, Figure 7). This evidence concerns the gene NFE2L2 and squamous cell intraepithelial neoplasia.