Nrf2 antioxidant enzymes to treat ulcerative colitis are the glutamate-cysteine ligase catalytic subunit (GCLC), NAD(P)H quinone dehydrogenase 1 (NQO1), hemeoxygenase-1 (HO-1), and glutamate-cysteine ligase modifier (GCLM). The gene discussed is HMOX1; the disease is ulcerative colitis.