To explore the molecular mechanism by which citromycin modulates the migration and invasion of human ovarian cancer cells, we examined whether three members of the mitogen-activated protein kinase (MAPK) family (ERK1/2, MAPK8/JNK, and p38) and serine-threonine protein kinase B (AKT) were associated with the effects of citromycin on the migration and invasion of SKOV3 and A2780 cells. The gene discussed is MAPK3; the disease is ovarian carcinoma.