The sulfated polysaccharide (SIP-SII) from Sepiella maindroni ink was shown to inhibit EGF-induced migration and invasion of human epidermoid carcinoma KB cells [51] and human ovarian carcinoma SKOV-3 cells [52] by suppressing the epidermal growth factor receptor (EGFR)-mediated Akt and p38 MAPK cascades and subsequently inhibiting MMP-2 expression. The gene discussed is EGFR; the disease is squamous cell carcinoma.