MMP9 and melanoma: Laminaran sulfate isolated from the brown alga Fucus evanescens was shown to be a potent anti-migratory agent by inhibiting MMP-2 and MMP-9 activity in human colorectal adenocarcinoma (HCT116 cells), malignant melanoma (SK-MEL-5 cells), and breast adenocarcinoma (MDA-MB-231 cells) [44].