In the multivariable analysis, both serum IgE and CML levels remained independent factors for ISR in patients with T2DM after adjusting for age, sex, body mass index, smoking, dyslipidemia, hypertension, HbA1c, left ventricular ejection fraction, use of statins, number of diseased vessel, class B2/C lesions, bifurcation, chronic total occlusions, and stent diameter. This evidence concerns the gene IGHE and metabolic syndrome.