Serum levels of IgE and CML were higher in ISR group compared with non-ISR group (IgE: 187.10 (63.75–489.65) vs. 80.25 (30.65–202.50), p < 0.001; CML: 203.26 (164.50–266.84) vs. 174.26 (130.85–215.56), p < 0.001). The gene discussed is IGHE; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.