Serum IgE correlated positively with CML levels (all patients: r = 0.331, p < 0.001; ISR group: r = 0.433, p < 0.001; non-ISR group: r = 0.153, p = 0.023), even after adjusting for confounding factors (Table 2). The gene discussed is IGHE; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.