Since the genetic component may have an important role, the objectives of our study were (1) to determine the allelic frequencies and genotype distribution of polymorphisms CRP rs1800947, TNFA rs1800629, and IL6 rs1800795; (2) to identify the association of these polymorphisms on inflammatory status; and (3) to evaluate the effect of genetic variability and 6 months of treatment with PSCK9 inhibitors on inflammatory status in a cohort of patients with myocardial infarction before the age of 50 years and very high Lp(a) levels. This evidence concerns the gene IL6 and myocardial infarction.