The V. cholerae toxin is known to break down the double-stranded DNA, which alters the structure and causes mutations involving the PAX5 gene (encodes typically for the transcription factor B-cell specific activator protein (BSAP)) and other oncogenes in the B lymphocytes, which lead to abnormal lymphopoiesis and the production of the aberrant IgA, and later progress to lymphoma [3]. This evidence concerns the gene PAX5 and lymphoma.