SDC1 and Miyoshi myopathy: MM diagnosis and stratification are accomplished by genomic profiling of CD138+ cells isolated from bone marrow aspirates (BMAs) by clinical karyotyping and Fluorescent In Situ Hybridization (FISH) assays to identify the presence of canonical trisomies in odd-numbered chromosomes (hyperdiploid disease) and for translocations (non-hyperdiploid disease) which together allows for patient stratification and therapy selection, particularly for high-risk disease [13,15].