CA4 and cancer: Based on the combined anti-cancer therapy of NIR-induced thermotherapy and vascular disruption, Yuqing Liang et al. synthesized an injectable nanocomposite (NC) hydrogel using Prussian blue (PB) nanoparticles, combretastatin A4 (CA4), and gellan gum, which had tumor-suppressive ability due to significant tumor site retention and the sustained release of CA4 [51].