Gong et al. have produced EVs with high levels of stromal cell-derived factor 1α (SDF-1α) from MSCs transfected with SDF-1α plasmids and showed these EVs inhibited ischemic myocardial cell apoptosis and promoted cardiac endothelial microvascular regeneration in mice with myocardial infarction [120]. This evidence concerns the gene CXCL12 and myocardial infarction.