In addition, in an effort to increase the efficiency of gene delivery for cardiac regeneration, a recent study explored the use of sonoporation for the delivery of therapeutic genes to an MI rat model, using microbubbles conjugated to adenoviruses encoding for the Ca2+ ATPase 2a (SERCA2a) and connexin 43 (Cx43) genes [70]. Here, GJA1 is linked to myocardial infarction.