It is now well established that MAGEL-2 not only functions in cancer but also mediates in endosomal trafficking of 500 kDa protein called ‘WASH complex’ that includes a variety of proteins such as WASH1 (Wiskott Aldrich Syndrome 1), FAM21 (which contains 21 copies of a novel amino acid motif: ‘L-F-[D/E]3-10-L-F’), Strumpellin, SWIP (Strumpellin and WASH-Interacting Protein), and CCDC53 (Coiled Coil Domain Containing p53). This complex prevents lysosomal degradation of SG (Secretory Granule) and dense SG (type of organelles) proteins [57]. Here, WASHC4 is linked to cancer.