With the increasing degree of carotid atherosclerosis in patients with ICVD, the levels of Cyst‐C and MMP‐9 and homocysteine (Hcy) were significantly increased, and juvenile Cyst‐C, MMP‐9, and Hcy were independent risk factors for the formation of carotid atherosclerostic plaque (CAP) (Fu, 2019). The gene discussed is MMP9; the disease is carotid atherosclerosis.