VEGFA and diabetes mellitus: The potent effects of insulin-like growth factor-I (IGF-I) on proliferation and angiogenesis in different target tissues are identified.13 On the other hand, various studies have reported a decline in serum IGF-1 levels in diabetic animals or patients; therefore, it is an attractive therapeutic candidate for diabetes.14 IGF-1, as a potent growth hormone, is crucial to induce essential functions of VEGF.