As a crucial angiogenic factor, Vascular endothelial growth factor (VEGF), reportedly is related to many pathological complications, such as diabetes mellitus and cardiovascular disorders (including ischemic heart disease, coronary artery disease, atherosclerosis, and strokes).2,6 It has been reported that the reduction of VEGF level in diabetic cardiac tissue has a possible role in the impairment of myocardial angiogenesis and leads to impaired collateral formation. This evidence concerns the gene VEGFA and cardiovascular disorder.