As the first component of the three risk scores, CHF has been associated with worse outcomes in COVID-19 patients.9 In patients with hypertension, upregulation of the ACE-2 expression has been demonstrated to play a critical role in increasing the fatality of the COVID-19.4 In a pooled analysis conducted by Du et al,10 patients with hypertension were at 2.17-fold higher risk of mortality. The gene discussed is ACE2; the disease is COVID-19.