It has been shown that compared with normal gastric tissues, GC tissue contains a higher level of CD73 protein which is closely related to the stronger invasiveness, short overall survival (OS) and disease-free survival (DFS), advanced clinical stage, deeper tumor invasion, and distant metastasis via immunohistochemistry, the Kaplan-Meier analysis, univariate Cox proportional hazards modeling, and fluorescent staining [42–44]. This evidence concerns the gene NT5E and gonorrhea.