CD73 is found significantly upregulated in CRC tissues compared with normal tissues, and its high expression is closely related to poor tumor differentiation, extensive immune cell infiltration, short OS, advanced tumor stage, and metastasis according to the Kaplan-Meier analysis, univariate Cox proportional hazards regression model analysis, ROC curve, and multivariate analysis [63]. The gene discussed is NT5E; the disease is colorectal carcinoma.