CD73 plays an important role in promoting GI tumorigenesis by interfering with the RICS/LIMK/cofilin signaling axis in GC, TNDR2 in PC, and RAP1 that activates the AKT and MAPK signaling pathways and effect the downstream molecules such as cyclinD1 and c-Myc in HCC. This evidence concerns the gene AKT1 and hepatocellular carcinoma.