PPARGC1A and presbycusis: It’s also reported that the SIRT1/PGC-1α signaling pathway is involved in age-related hearing loss (Tian et al., 2014; Xue et al., 2016; Shen et al., 2018; Hao et al., 2019), and the downregulated SIRT/PGC-1α increases the incidence of age-related hearing loss via promoting the apoptosis of cochlear hair cells.