SIRT1 and hearing loss disorder: Recent studies have reported that SIRT1 dysfunction is related to abnormal oxidative stress in cochlear cells and hearing loss (Kim et al., 2016; Xiong et al., 2017; Xiong et al., 2019; Affortit et al., 2021), and resveratrol treatment exhibits a protective effect against oxidative stress in cochlear hair cells by enhancing SIRT1 deacetylase activity (Xiong et al., 2019).