SOD1 and type 2 diabetes mellitus: In accordance with the above-mentioned results in individuals with type 2 diabetes, we found that empagliflozin, particularly, the empagliflozin-metformin 12-week treatment, acted antioxidatively, the effect of the combination being enhanced to the level where all studied antioxidative parameters (TAS, GPx, SOD) significantly increased with a concomitant decrease in the studied prooxidant parameters (AOPP and isoprostane), compared to the individual drugs or the control group.