A positive outcome of p53 and 14-3-3 protein interactions is also the protection of p53 from MDM2-mediated proteasomal degradation, which leads to an increase in p53 transcriptional activity and cell cycle arrest, thus restoring the tumour-suppressing properties of p53 (Yang et al., 2003; Rajagopalan et al., 2008; Falcicchio et al., 2020). Here, TP53 is linked to neoplasm.