SIRT6 and Nasal polyposis: Furthermore, the upregulation of SIRT6 gene expression in nasal mucosal epithelial cells can inhibit the migration of high mobility group protein 1 (HMGB1) induced by lipopolysaccharide (LPS), suggesting that SIRT6 may inhibit the development of nasal polyps by altering inflammatory processes (Chen et al., 2017).