Furthermore, the upregulation of SIRT6 gene expression in nasal mucosal epithelial cells can inhibit the migration of high mobility group protein 1 (HMGB1) induced by lipopolysaccharide (LPS), suggesting that SIRT6 may inhibit the development of nasal polyps by altering inflammatory processes (Chen et al., 2017). This evidence concerns the gene HMGB1 and Nasal polyposis.