Subsequently, second-generation ALK inhibitors such as ceritinib, alectinib, and brigatinib are the currently available oral ALK inhibitors approved by the European Medicines Agency for the first-line or second-line (ie, post-crizotinib) treatment (SLT) of ALK-positive advanced NSCLC.8–10. The gene discussed is ALK; the disease is non-small cell lung carcinoma.