The aim of the present study was to delineate the cost-effectiveness of lorlatinib compared with combination of pemetrexed with platinum-based chemotherapy (P-ChT) such as carboplatin or cisplatin for the treatment of patients with ALK-positive NSCLC previously treated with ≥1 second-generation TKI in Greece. The gene discussed is ALK; the disease is non-small cell lung carcinoma.