It was noticed that the nine pairs of PKD1 homozygotes were associated with a severe phenotype in 14 individuals, and 21.4% of the patients with homozygotes (3/14) were premature neonate died and others (71.4%, 10/14) exhibited in utero onset ADPKD (Cornec-Le Gall et al., 2018; Al-Hamed et al., 2019; Garel et al., 2019; Durkie et al., 2021). This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.