We identified a 12 pyroptosis-associated gene signature for the prognosis of colorectal cancer, including CAS P3, CHMP2A, CHMP2B, CHMP3, CHMP4C, CHMP6, CHMP7, GSDME, HMGB1, IL1A, IRF2, and TP63. This evidence concerns the gene HMGB1 and colorectal cancer.