We identified a 12 pyroptosis-associated gene signature for the prognosis of colorectal cancer, including CAS P3, CHMP2A, CHMP2B, CHMP3, CHMP4C, CHMP6, CHMP7, GSDME, HMGB1, IL1A, IRF2, and TP63. Here, CHMP3 is linked to colorectal cancer.