We identified a 12 pyroptosis-associated gene signature for the prognosis of colorectal cancer, including CAS P3, CHMP2A, CHMP2B, CHMP3, CHMP4C, CHMP6, CHMP7, GSDME, HMGB1, IL1A, IRF2, and TP63. Here, CHMP4C is linked to colorectal cancer.