By inhibiting the key inflammatory signaling pathways including NF-κB and JNK pathways (43), as well as various proinflammatory signaling molecules and cytokines, the connection between obesity and IR can be blocked, finally causing significant tissue damage such as liver steatosis and fibrosis (44, 45). The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.