INS and cancer: Among all the pathways enriched, the top 10 most significant pathways were as follows: proteoglycans in cancer, miRNAs in cancer, ubiquitin-mediated proteolysis, regulation of actin cytoskeleton, Ras signaling pathway, human papillomavirus infection, PI3K-Akt signaling pathway, cellular senescence, ErbB signaling pathway, and insulin resistance (Figure 6).