Our data are in parallel with previous studies about the oncogenic role of CaSR in breast cancer, melanoma, prostate, kidney, colon and gastric cancers.12,19-25 NPS-2143 treatment resulted in significant suppression of breast cancer cell viability and the effect of growth suppression was significantly started at low NPS-2143 concentration (0.5μM) and maintained to the maximum effect at 10 μM. The gene discussed is CASR; the disease is melanoma.