MAPK3 and renal cell carcinoma: In renal cell carcinoma, CaSR promotes cell migration via enhancing ERK1/2 and other factors’ activities.24 In thyroid cancer cells, the CaSR induces cell migration via interaction with β1 integrin.21 Collectively, these findings confirm the anti-migratory as well as the anti-invasive effects of NPS-2143 in breast cancer.