Kim et al have shown that activation of the CaSR through high extracellular calcium results in breast cancer cells resistance to caspase-independent apoptosis by hindering nuclear accumulation of AIF.11 In our condition, we reported that NPS-2143 treatment of breast cancer cells resulted in caspase-dependent apoptosis as shown by activation of caspase3/7. The gene discussed is AIFM1; the disease is breast carcinoma.