RBL2 and small cell lung carcinoma: Ng et al transfected a Cre-activated allele of Cas9 into Trp53flox/flox, Rb1flox/flox murine models of SCLC using the adenoviral vectors harboring the Cre recombinase and sgRNAs targeting either p130 (Rbl2) or p107 (Rbl1).