The loss of alleles on chromosome 3 has been detected in about 90% of SCLC and 50% of NSCLC cases.12-14 The main oncogenes activated in NSCLC are epidermal growth factor receptor, anaplastic lymphoma kinase (ALK), Myc, Bcl-2, and KRAS. The gene discussed is ALK; the disease is non-small cell lung carcinoma.