Moreover, HMGA2 is involved in the initiation of epithelial-to-mesenchymal transition (EMT) in a human PC cell line (PC-3).22 These experiments recommend that HMGA2 has an important impact on various tumors, such as PC, which is supported by the re-expression of HMGA2 as a prognostic tumor marker. This evidence concerns the gene HMGA2 and pachyonychia congenita.