These changes diminish the synthesis of apolipoprotein C which accelerates the degradation of fatty acid in plasma, after the use of Ex-4 and stimulation of GLP-1R signaling pathway.97 Experiments have shown that incubation of ob/ob mice with Ex-4 exerted anti-hepatic steatosis and -fibrosis capacities.98 The modulatory effect of Ex-4 on hepatic steatosis is done by reducing lipid droplets. The gene discussed is GLP1R; the disease is Hepatic steatosis.