By affecting on multiple targets, honey interferes with cancer cell’s signaling pathways, including apoptosis induction; mitochondrial pathway activation; cell cycle arrest; insulin signaling and oxidative stress modulation; inflammation amelioration; inhibition of angiogenesis and cell proliferation; immune cells and TNF-α, IL-1β, IFN-γ, and p53 stimulation; and lipoprotein oxidation, IL-1, IL-10, COX-2, lipoxygenases, and prostaglandin E2 inhibition. This evidence concerns the gene TP53 and cancer.