NR1H4 and hypertensive disorder: It is generally believed that the intestinal flora produces metabolites, such as farnesoid X Receptor (FXR) signal antagonists, TGR5 signal agonists, β-taurocholic acid, and other primary bile acids [13, 14], thereby promoting atherosclerosis and calcification of blood vessel walls by affecting cholesterol metabolism to indirectly affecting the occurrence and development of hypertension.